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| Eke,Ifeanyi Gabriel; Ezeh,Ikenna Onyema; Ezeudu,Terry Adaeze; Eze,Ukamaka Uchenna; Anaga,Aruh Ottah; Onyeyili,Patrick Azubuike. |
| This study evaluated the efficacy of combination therapy of secnidazole-diminazene aceturate (SEC-DA) in late treatment of dogs experimentally infected with relapsing strain of Trypanosoma brucei brucei. Fifteen dogs were randomly assigned to 5 groups (A - E) of 3 per group. Group A (uninfected untreated), B (infected untreated), C (infected and treated with DA (3.5 mg/kg) IM stat), D (infected and treated with secnidazole (SEC) (100 mg/kg) orally for 5 days and DA (3.5 mg/kg) IM stat), E (infected and treated with SEC (200 mg/kg) orally for 5 days and DA (3.5 mg/kg) IM stat). Dogs were infected intraperitoneally with 5 x 105 trypanosomes and treatment started 14 days post-infection. Data on parasitaemia, hematology and rectal temperature were recorded.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Secnidazole; Diminazene aceturate; Combination therapy; Trypanosomosis; Dogs; Relapse. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100521 |
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| Denardi,Laura Bedin; Mario,Débora Alves Nunes; Loreto,Érico Silva; Santurio,Janio Morais; Alves,Sydney Hartz. |
| In vitro interaction between tacrolimus (FK506) and four azoles (fluconazole, ketoconazole, itraconazole and voriconazole) against thirty clinical isolates of both fluconazole susceptible and -resistant Candida glabrata were evaluated by the checkerboard microdilution method. Synergistic, indifferent or antagonism interactions were found for combinations of the antifungal agents and FK506. A larger synergistic effect was observed for the combinations of FK506 with itraconazole and voriconazole (43%), followed by that of the combination with ketoconazole (37%), against fluconazole-susceptible isolates. For fluconazole-resistant C. glabrata, a higher synergistic effect was obtained from FK506 combined with ketoconazole (77%), itraconazole (73%), voriconazole... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Candida glabrata; Azole resistance; FK506; Combination therapy. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000100125 |
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